The First Mammalian Aldehyde Oxidase Crystal Structure
نویسندگان
چکیده
منابع مشابه
The first mammalian aldehyde oxidase crystal structure: insights into substrate specificity.
BACKGROUND Aldehyde oxidases have pharmacological relevance, and AOX3 is the major drug-metabolizing enzyme in rodents. RESULTS The crystal structure of mouse AOX3 with kinetics and molecular docking studies provides insights into its enzymatic characteristics. CONCLUSION Differences in substrate and inhibitor specificities can be rationalized by comparing the AOX3 and xanthine oxidase stru...
متن کاملCrystal structure and mechanism of action of the xanthine oxidase-related aldehyde oxidoreductase from Desulfovibrio gigas.
The crystal structure of the aldehyde oxidoreductase (Mop) from the sulphate-reducing bacterium Destdjovibrio gigas has been analysed and refined to 1.8A (0.18 nm) resolution in its native ‘desulpho’ form, as well as in ‘resulphurated’, oxidized, reduced and alcohol-bound forms [1,2], allowing a detailed look at several structural aspects relevant to catalysis. In analogy with eukaryotic xanthi...
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LPS is a potent bacterial endotoxin that triggers the innate immune system. Proper recognition of LPS by pattern-recognition receptors requires a full complement of typically six acyl chains in the lipid portion. Acyloxyacyl hydrolase (AOAH) is a host enzyme that removes secondary (acyloxyacyl-linked) fatty acids from LPS, rendering it immunologically inert. This activity is critical for recove...
متن کاملHepatic Aldehyde Oxidase
Previous reports on rabbit liver aldehyde oxidase described the purification and some properties of the enzyme (1) and the differential inhibition of electron transfer to various acceptors (2). The latter study furnished evidence for the participation of several electron carriers in the internal electron transport sequence of the enzyme. The present communication summarizes the results of studi...
متن کاملCrystal Structure of Heterotetrameric Sarcosine Oxidase
Introduction The concentration of serum creatinine is widely used as an indicator of renal function. Sarcosine oxidase (SO) has been used in the enzymatic determination of creatinine in the clinical laboratory. SO has been isolated from various bacterial strains. It was first purified from Corynebacterium sp. U-96 (SO-U96) and shown to be a heterotetrameric enzyme. SO-U96 is a complex, bifuncti...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2012
ISSN: 0021-9258
DOI: 10.1074/jbc.m112.390419